Oxidative damage to RNA: mechanisms, consequences, and diseases
نویسندگان
چکیده
منابع مشابه
Oxidative Damage to RNA in Neurodegenerative Diseases
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion disease, subacute sclerosing panencephalitis, and xeroderma pigmentosum. An early involvement of RNA oxidation of vulnerable neuronal population in the neurodegenerative diseases has been demonstrate...
متن کاملRole of Oxidative RNA Damage in Chronic-Degenerative Diseases
Normal cellular metabolism and exposure to ionizing and ultraviolet radiations and exogenous agents produce reactive oxygen species (ROS). Due to their reactivity, they can interact with many critical biomolecules and induce cell damage. The reaction of ROS with free nucleobases, nucleosides, nucleotides, or oligonucleotides can generate numerous distinct modifications in nucleic acids. Oxidati...
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Atherosclerosis, the hardening of arteries under oxidative stress is related to oxidative changes of low density lipoproteins (LDL). The antioxidants prevent the formation of oxidized LDL during atherogenesis. Perhaps more than one mechanism is involved in the atherosclerosis disease where LDL is oxidized in all the cells of arterial wall during the development of this disease. The oxidation of...
متن کاملTranscription-coupled repair of oxidative DNA damage in human cells: mechanisms and consequences.
متن کامل
Oxidative DNA damage: mechanisms, mutation, and disease.
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8-oxo-2'deoxyguanosine. This lesion has been the focus of intense research interest and been ascribed much importance, largely to th...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2010
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-010-0277-y